Good news: calendula isn’t known for having many adverse side effects. It is possible, though, that this herb could cause an allergic reaction, especially in people with known allergies to marigolds or plants in the Asteraceae family. It might also interfere with certain medications, like sedatives, blood pressure meds, or medications for diabetes. If you’re concerned, check with your doctor about potential contraindications before plunking down your cash on calendula.